Independent study conducted with participants in the Framingham Heart Study (FHS) and the Bogalusa Heart Study (BHS) to test the validity and reliability of DANA as a measure of cognitive performance in comparison to traditional assessments. Objectives: Determine the extent to which smartphone-based DANA measures of cognitive performance correlate with traditional, validated paper and pencil neuropsychological test measurements in two diverse cohorts. Methods: 406 FHS participants (average age of 57 years old) and 59 BHS participants (average age of 49 years old), all characterized as cognitively normal, completed DANA cognitive testing in a remote, self-administered and unsupervised manner. DANA test results were then compared to results from the participants’ most recent neuropsychological test administered by trained personnel as part of ongoing testing of FHS and BHS participants. Results: Performance on the smartphone-based DANA cognitive tasks was congruent with cognitive performance measured by using traditional, validated paper and pencil neuropsychological protocols in these two geographically distinct and diverse cohorts. The findings suggest that the DANA cognitive tests can assess aspects of cognitive function known to be associated with Alzheimer disease and Alzheimer disease-related dementia.